Multiplex analysis of serum cytokines in humans with hantavirus pulmonary syndrome
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Authors
Morzunov, Sergey P.
Khaiboullina, Svetlana F.
St Jeor, Stephen
Rizvanov, Albert A.
Lombardi, Vincent C.
Issue Date
2015
Type
Article
Language
en_US
Keywords
hantavirus pulmonary syndrome , serum , cytokines , chemokines , growth factors , immune response , hantaviruses
Alternative Title
Abstract
Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability without a visible cytopathic effect. For this reason, it has been suggested that the pathogenesis of HPS is indirect with immune responses, such as cytokine production, playing a dominant role. In order to investigate their potential contribution to HPS pathogenesis, we analyzed the serum of hantavirusinfected subjects and healthy controls for 68 different cytokines, chemokines, angiogenic, and growth factors. Our analysis identified differential expression of cytokines that promote tissue migration of mononuclear cells including T lymphocytes, natural killer cells, and dendritic cells. Additionally, we observed a significant upregulation of cytokines known to regulate leukocyte migration and subsequent repair of lung tissue, as well as cytokines known to increase endothelial monolayer permeability and facilitate leukocyte transendothelial migration. Conversely, we observed a downregulation of cytokines associated with platelet numbers and function, consistent with the thrombocytopenia observed in subjects with HPS. This study corroborates clinical findings and extends our current knowledge regarding immunological and laboratory findings in subjects with HPS.
Description
Citation
Morzunov, S. P., Khaiboullina, S. F., St. Jeor, S., Rizvanov, A. A., & Lombardi, V. C. (2015). Multiplex Analysis of Serum Cytokines in Humans with Hantavirus Pulmonary Syndrome. Frontiers in Immunology, 6. doi:10.3389/fimmu.2015.00432
Publisher
Frontiers in Immunology
License
Attribution 4.0 International
Journal
Volume
Issue
PubMed ID
ISSN
1664-3224