Microbial Sterolomics as a Chemical Biology Tool
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Authors
Haubrich, Brad A.
Issue Date
2018
Type
Article
Language
Keywords
algal sterols , ergosterol biosynthesis , infectious disease , lipidomics , oxyphytosterol , pharmacognosy , phytosterol , sterolomics
Alternative Title
Abstract
Metabolomics has become a powerful tool in chemical biology. Profiling the human sterolome has resulted in the discovery of noncanonical sterols, including oxysterols and meiosis-activating sterols. They are important to immune responses and development, and have been reviewed extensively. The triterpenoid metabolite fusidic acid has developed clinical relevance, and many steroidal metabolites from microbial sources possess varying bioactivities. Beyond the prospect of pharmacognostical agents, the profiling of minor metabolites can provide insight into an organism's biosynthesis and phylogeny, as well as inform drug discovery about infectious diseases. This review aims to highlight recent discoveries from detailed sterolomic profiling in microorganisms and their phylogenic and pharmacological implications.
Description
Citation
Haubrich, B. (2018). Microbial Sterolomics as a Chemical Biology Tool. Molecules, 23(11), 2768. doi:10.3390/molecules23112768
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License
Creative Commons Attribution 4.0 International
Journal
Volume
Issue
PubMed ID
ISSN
1420-3049