Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
Loading...
Authors
Loomis, Dana
Guha, Neela
Kogevinas, Manolis
Fontana, Vincenzo
Gennaro, Valerio
Kolstad, Henrik A.
McElvenny, Damien M.
Sallmen, Markku
Saracci, Rodolfo
Issue Date
2019
Type
Article
Language
Keywords
Alternative Title
Abstract
To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. Methods Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. Results Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. Conclusion This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.
Description
Citation
Loomis, D., Guha, N., Kogevinas, M., Fontana, V., Gennaro, V., Kolstad, H. A., … Saracci, R. (2018). Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis. Occupational and Environmental Medicine, 76(3), 157�"162. doi:10.1136/oemed-2018-105131
Publisher
License
Creative Commons Attribution-NonCommercial 4.0 International
Journal
Volume
Issue
PubMed ID
ISSN
1351-0711