Amyotrophic Lateral Sclerosis: An Exploration into the SOD1 Protein and a Representative Case Study
Loading...
Authors
Lopez, Roberto
Issue Date
2013
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the continual deterioration of upper and lower motor neurons, which invariably leads to death. Like other complex diseases, no particular cause can be attributed to the great majority of ALS cases. Clear pathological mechanisms have not been elucidated, but current research is making headway into understanding superoxide dismutase 1 (SOD1), an important antioxidant that is heavily implicated in the pathogenesis of familial ALS. The goals of this thesis are to help understand the molecular basis of SOD1 in relation to ALS and to demonstrate the dire need for a greater understanding of this unrelenting disease. This paper contains a general review of ALS disease, followed by a molecular exploration of the SOD1 gene. Finally, a representative case study is included at the end to highlight the disease from a clinical perspective.
Description
The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint.
Citation
Publisher
License
In Copyright(All Rights Reserved)