The Effects of Omega-3 and Omega-6 Fatty Acids on the Epigenetic Landscape of Human Mammary Carcinoma (MDA-MB-231)
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Authors
Abbas, Tayeb
Issue Date
2018
Type
Thesis
Language
en_US
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Abstract
Breast cancer is the most common form of cancer among women, with over 250,000 new diagnoses in the United States this year alone. In addition, breast cancer has been the cause of death for more than 40,000 women in the United States in 2017. While there are many genetic and environmental effects that play a role in cancer formation, the role of epigenetics and dietary habits have been shown to have varying effects as well. Previous research in the Pardini Lab has shown that omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have anti-inflammatory activity and depress tumorigenesis, while high amounts of omega-6 PUFAs such as linoleic acid (LA) and arachidonic acid (AA) increase tumor proliferation. Epigenetic processes have been reported to regulate cancer proliferation. Previous studies have shown that increased methylation of oncogenes and tumor suppressor drugs have decreased and increased tumor formation, respectively, which favors tumor proliferation. Ultimately, the focus of this study is to examine the effects of PUFAs on epigenetic patterns on the breast cancer cell line, MDA-MB-231. We hypothesize that DHA, EPA, Azacytidine, and Panobinostat treatments will decrease methylation levels of DNA, while omega-6 PUFAs such as linoleic acid (LA) and arachidonic acid (AA) will promote methylation.
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In Copyright