Genentech Senior Design Project: Purification of a Ranibizumab-like Protein
Authors
Stewart, Owen
Issue Date
2018
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
This project was completed by a Senior Design team of the Deparment of Chemical and Materials Engineering at the University of Nevada, Reno. The goal of this project was to design a process to isolate and purify a monoclonal antibody similar to Ranibizumab, or “Lucentis”, which is used in the treatment of wet age-related macular degeneration of the eyes, a leading cause of blindness. A focus on the chromatographical purification of Lucentis is provided, and both base and alternate cases for a complete process are presented. A discussion of relevant engineering economics and considerations for scale up of such a process are also included.
Description
The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint.
Citation
Publisher
License
In Copyright