Motor Axon Guidance to Eye Muscles: Slit/Robo Molecular Signals
Loading...
Authors
Louw, J. Sterling
Issue Date
2020-05-01
Type
Thesis
Language
en_US
Keywords
Alternative Title
Abstract
Axons must navigate during development for neurons to make connections to their target areas. Slit/Robo signals are still poorly understood for its influence on axonal navigation. Slit/Robo signaling in previous studies appears to have a repulsive function, however positive functions have been seen in other papers. The goal of my study was to determine if Slit/Robo signals have any function in guiding abducens axons to their eye muscle targets during mouse embryo development. I examined the abducens nerve in E12 mouse embryos of several mutant phenotypes involving Slit and Robo to determine their in vivo affects on axonal projections and axon-axon fasciculation. I observed distinct phenotypic alterations in Robo mutants that hindered the ability of the abducens nerve to navigate towards target destinations and maintain fasciculated as an axon bundle. I concluded that Slit/Robo signaling has an important role in fasciculation and navigation of motor axons.
Description
The University of Nevada, Reno Libraries will promptly respond to removal requests related to content that violates intellectual property laws, data protections, or has been uploaded without creator consent. Takedown notices should be directed to our ScholarWolf team (scholarwolf@library.unr.edu) with information about the object, including its full URL and the nature of your complaint.
Citation
Publisher
License
In Copyright