Acute leukemia in congenital methehemoglobinemia-an enigma to explore'
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Authors
Al-Khafaji, Jaafar
Sharma, Mokshya
Nayeemuddin, Khazi
Al-Qaysi, Iman A.
Al-Mashhadani, Arshad A.
Taha, Mohamed E.
Abdalla, Abubaker O.
Issue Date
2019
Type
Article
Language
Keywords
Congenital methemoglobinemia , acute leukemia , hypoxia , acquired methemoglobinemia , deprivation , oxygen , bone marrow
Alternative Title
Abstract
Congenital methemoglobinemia is a rare disease, resulting in increased oxygen affinity and impaired oxygen delivery to the tissues. While there have been studies that have linked acquired methemoglobinemia in almost 79% of leukemia patients, to the best of our knowledge, this is the first case of leukemia development in a patient with congenital methemoglobinemia. Chronic deprivation of oxygen to metabolically active bone marrow can theoretically lead to hematopoietic disorders. It would be interesting to further investigate if presence of congenital methemoglobinemia is a risk factor for developing acute leukemia.
Description
Citation
Al-Khafaji, J. F., Sharma, M., Nayeemuddin, K., Al-Qaysi, I. A., Al-Mashhadani, A. A., Taha, M. E., & Abdalla, A. O. (2018). “Acute leukemia in congenital methehemoglobinemia - an enigma to explore.” Journal of Community Hospital Internal Medicine Perspectives, 9(1), 55–58. doi:10.1080/20009666.2018.1555431
Publisher
Journal
Volume
Issue
PubMed ID
ISSN
2000-9666