Metadherin: A Therapeutic Target in Multiple Cancers
Authors
Dhiman, Gourav
Srivastava, Neha
Goyal, Mehendi
Rakha, Emad
Lothion-Roy, Jennifer
Mongan, Nigel P.
Miftakhova, Regina R.
Khaiboullina, Svetlana F.
Rizvanov, Albert A.
Baranwal, Manoj
Issue Date
2019
Type
Article
Language
Keywords
cancer , microRNA , chemoresistance , immunotherapy , metadherin
Alternative Title
Abstract
Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in non-malignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-kB, Wnt/beta-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.
Description
Citation
Dhiman, G., Srivastava, N., Goyal, M., Rakha, E., Lothion-Roy, J., Mongan, N. P., … Baranwal, M. (2019). Metadherin: A Therapeutic Target in Multiple Cancers. Frontiers in Oncology, 9. doi:10.3389/fonc.2019.00349
Publisher
License
Creative Commons Attribution 4.0 International
Journal
Volume
Issue
PubMed ID
ISSN
2234-943X