Polycystic Kidney Disease: Literature Review on the Mechanism of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Reduction of Cyst Growth in Patients with ADPKD and a Clinical Case Study
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Authors
Gandhi, Niraj
Issue Date
2014
Type
Thesis
Language
en_US
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Abstract
Polycystic Kidney Disease (PKD) is a genetic disorder characterized by a growth
of multiple cysts in the kidney which, in most cases, culminates in end stage renal failure.
A clinical case study was done to highlight the clinical manifestations and the
progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Currently
there are no treatments or cures for PKD with the exception of dialysis and kidney
transplantation for patients in kidney failure. Exploration of the role of PKD1 and PKD2
in cystogenesis had yielded potential treatment alternatives for ADPKD such as the use
of mammalian target of rapamycin (mTOR) inhibitors to reduce cyst growth and preserve
kidney function.
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In Copyright(All Rights Reserved)