Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence
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Authors
Shi, Junchao
Zhang, Yunfang
Chen, Qi
Issue Date
2016
Type
Article
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Abstract
In utero exposure to environmental endocrine disruptors can cause transgenerational effects in the males of subsequent generations. DNA methylation (5 mC) was suggested, but being challenged as the molecular carrier of such epigenetic information. In a recent study, Schuster et al. show a changed small RNA profile changed in the sperm of F3 generation after F0 in utero vinclozolin exposure, suggesting additional transgenerational epigenetic carriers for endocrine disruptor effects, other than DNA methylation.
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Citation
Shi, J., Zhang, Y., & Chen, Q. (2016). Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence. Environmental Epigenetics, 2(2), dvw014. doi:10.1093/eep/dvw014
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PubMed ID
ISSN
2058-5888