Biomedical approach in autism spectrum disorders-the importance of assessing inflammation
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Authors
Mijatovic, Tatjana
Siniscalco, Dario
Subramanian, Krishnamurthy
Bosmans, Eugene
Lombardi, Vincent C.
De Meirleir, Kenny L.
Issue Date
2018
Type
Article
Language
en_US
Keywords
autism , inflammation , immune dysfunction , intestinal dysfunctions , biomedical evaluation
Alternative Title
Abstract
Autism spectrum disorders (ASD) are severe heterogeneous neurodevelopmental disorders characterized by dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and nonverbal behaviors. Published findings have identified widespread changes in the immune systems of children with autism, at the systemic and cellular levels, suggesting that autism may, in fact, be a systemic disorder with connections to abnormal immune responses. Evaluating autism is hindered by a lack of specific biomarkers, making these pathologies difficult to diagnose. A critical priority for the future of ASD management is the identification of potential targets for the development of diagnostic and therapeutic strategies. The purpose of this brief report is to raise awareness regarding the involvement of different inflammatory processes in ASD and the need to assess them as a part of a biomedical evaluation. An extensive analysis of biomarkers relating to inflammation, immune dysfunctions, intestinal dysfunctions and infections will assist in the management of the autistic patient through a more personalized therapy.
Description
Citation
Mijatovic, T., Siniscalco, D., Subramanian, K., Bosmans, E., … C. Lombardi, V. (2018). Biomedical approach in autism spectrum disorders�"the importance of assessing inflammation. AIMS Molecular Science, 5(3), 173�"182. doi:10.3934/molsci.2018.3.173
Publisher
AIMS Molecular Science
License
Attribution 4.0 International
Journal
Volume
Issue
PubMed ID
ISSN
2372-0301