Wnt signaling controls anteroposterior polarity in C. elegans mechanosensory neurons
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Authors
Oliver, Daniel K.
Issue Date
2013
Type
Dissertation
Language
Keywords
Axon guidance , C. elegans , Neuron outgrowth , Neuron polarity , Partial Redundancy , Wnt Signaling
Alternative Title
Abstract
The Wnt family of secreted proteins is responsible for a multitude of
developmental processes, often functioning as a morphogen during early
development. Here, we address the impact of Wnt signaling on the
anteroposterior (AP) polarization of C. elegans mechanosensory neurons during
embryonic development. We also provide evidence to support a model whereby
partially redundant Wnt signals integrate to provide a robust system of checks
and balances to ensure the proper polarization of cells along the AP axis.
Namely, we found that all five C. elegans Wnt genes contribute to the
polarization of both the anterior lateral mechanosensory neuron (ALM) and the
posterior lateral mechanosensory neuron (PLM). Additionally, we revealed
previously unidentified roles for C. elegans Wnt receptors in receiving this signal.
Lastly, we discovered a partial redundancy shared between the three C. elegans
disheveled genes in mediating the downstream cellular processes that Wnt
signaling controls.
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License
In Copyright(All Rights Reserved)