Association between physical health and cardiovascular diseases: Effect modification by chronic conditions
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Authors
Saquib, Nazmus
Brunner, Robert
Desai, Manisha
Allison, Matthew
Garcia, Lorena
Stefanick, Marcia L.
Issue Date
2018
Type
Article
Language
Keywords
Cardiovascular , epidemiology/public health , physical component summary score , RAND-36
Alternative Title
Abstract
This study assessed whether the physical component summary score of the RAND-36 health-related quality-of-life survey was associated with incidence of coronary heart disease, stroke, congestive heart failure, angina, or peripheral arterial disease, and whether baseline chronic conditions modified these associations. Methods: Analysis was limited to 69,155 postmenopausal women (50-79years) in the Women's Health Initiative Study who had complete data on the RAND-36, the outcomes, and covariates. Chronic conditions were defined as blood pressure 140/90mm or self-reported heart disease, diabetes, hypertension, arthritis, asthma, emphysema, cancer, and/or cholesterol-reducing medication use. Outcomes data were ascertained during follow-up (1993-2005) with medical records. Results: There were 2451 coronary heart disease, 1896 stroke, 1533 congestive heart failure, 1957 angina, and 502 peripheral arterial disease events during follow-up (median 8.2years). Participants in the lowest physical component summary quintile, compared to the highest, had a significantly higher risk of developing coronary heart disease (hazard ratio (95% confidence interval) 2.0 (1.7, 2.3)), stroke (1.8 (1.5, 2.2)), angina (2.4(2.0, 2.9)), and peripheral arterial disease (3.0 (2.0, 4.4)), irrespective of chronic conditions. Interactions between physical component summary and existing chronic conditions were not significant for any outcome except congestive heart failure (p=0.005)
after adjustment, participants in the lowest physical component summary quintile and with any chronic condition had nearly a twofold higher risk of congestive heart failure (Yes=4.4 (3.3, 5.8) vs No=2.4 (1.2, 4.3)). Conclusion: We found a low physical component summary score was a significant risk factor for individual cardiovascular disease incidence in postmenopausal women.
after adjustment, participants in the lowest physical component summary quintile and with any chronic condition had nearly a twofold higher risk of congestive heart failure (Yes=4.4 (3.3, 5.8) vs No=2.4 (1.2, 4.3)). Conclusion: We found a low physical component summary score was a significant risk factor for individual cardiovascular disease incidence in postmenopausal women.
Description
Citation
Saquib, N., Brunner, R., Desai, M., Allison, M., Garcia, L., & Stefanick, M. L. (2018). Association between physical health and cardiovascular diseases: Effect modification by chronic conditions. SAGE Open Medicine, 6, 205031211878533. doi:10.1177/2050312118785335
Publisher
Journal
Volume
Issue
PubMed ID
ISSN
2050-3121